Carbohydrate-binding Protein alters Body’s Reaction to HIV Infection

Immune system of human body is majorly dependent on “helper” T cells for its proper functioning. PDI (protein disulfide isomerase) is an essential enzyme that is responsible for the optimal functioning of T cells especially in the patients who suffer with AIDS. PDI enzymes alter the outer protein envelope of HIV and therefore enhance its interaction with CD4 molecule on the surface of “helper” T cells. Galectin-9 is a carbohydrate-binding protein that cancels the action of PDI enzymes by trapping them thereby making the cells susceptible to the invasive action of HIV.